SB-334867,CID 6604926
SB-334867 (free base)
CAS: 792173-99-0
Molecular Formula: C17H13N5O2
SB-334867,CID 6604926 - Names and Identifiers
| Name | SB-334867 (free base) |
| Synonyms | SB-334867,CID 6604926 SB-334867 (free base) N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA 1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea 1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867 |
| CAS | 792173-99-0 |
SB-334867,CID 6604926 - Physico-chemical Properties
| Molecular Formula | C17H13N5O2 |
| Molar Mass | 319.32 |
| Density | 1.472 |
| Boling Point | 450.5±30.0 °C(Predicted) |
| Solubility | DMSO: ≥ 49 mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 10.21±0.43(Predicted) |
| Storage Condition | room temp |
| In vitro study | In CHO-OX1 cells, SB-334867 inhibited orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses, pKB 7.27 and 7.23, respectively, to UTP (3 microM). The induced calcium response had no effect. |
| In vivo study | In male and female rats, sb-334867 (30 mg/kg, I. p.) significantly reduced natural and orexin-A-induced food intake. In rats, 867 (2 mg/kg, I. v.) blocks the effect of antipsychotic drugs on the activity of dopamine neurons. In rats, SB-334867 also inhibits the development of tolerance to morphine analgesia. |
SB-334867,CID 6604926 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.132 ml | 15.658 ml | 31.317 ml |
| 5 mM | 0.626 ml | 3.132 ml | 6.263 ml |
| 10 mM | 0.313 ml | 1.566 ml | 3.132 ml |
| 5 mM | 0.063 ml | 0.313 ml | 0.626 ml |
Last Update：2024-01-02 23:10:35
SB-334867,CID 6604926 - Reference Information
| biological activity | SB-334867 is a selective orexin-1 (OX1) receptor antagonist. SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
| Target | Value |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: SB-334867 (free base) Visit Supplier Webpage Request for quotationCAS: 792173-99-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: SB-334867 (free base) Visit Supplier Webpage Request for quotationCAS: 792173-99-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History